Abstract

SOLUBILITY ENHANCEMENT TECHNIQUES: A REVIEW ARTICLE

Shashank Mani Yadav* and Pranav Kumar Upadhyay

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Abstract

Solubility plays a crucial role whenever a drug's effectiveness depends on its ability to disperse homogeneously in the liquid phase. On the other hand, the majority of active pharmacological substances have low water solubility. One of the most important factors in the success of formulation development is the solubility of the drugs. A difficult challenge in drug development is improving the drug's solubility, dissolution rate and bioavailability; over 40% of novel chemicalentities reported to date are poorly water-soluble medications. Despite having promising pharmacokinetic properties, a large number of innovative drugs are unable to enter the market because of poor water solubility. The aqueous solubility of a drug also affects the physical, chemical and dose stability; it sets a standard for purity, dissolution rate and extent of absorption; and it achieves the desired concentration of the drug in systemic circulation in order to achieve the required pharmacological response in the systemic circulation. In this review, solubilization techniques such as chemical modification, physical modification and other methods were discussed as they open up new pathways for the production of potent and marketable drugs in Pharmaceutical Industry.

Keywords: Absorption; Bioavailability; Dissolution; Dispersion; Solubilization techniques.