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Abstract

DRUG SAFETY EVALUATION OF ANTI-PSYCHOTICS IN SCHIZOPHRENIA: A PROSPECTIVE OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL

K. Srilakshmi Silpa, Saripudi Aparna*, Pamidi Pradeep and Dr.N.Murali Krishna

Abstract

Background: Schizophrenia is a severe form of mental illness, with a variety of positive, negative, cognitive and mood symptoms, antipsychotic medications can have dramatic impact in patient life leads to many side effects. The purpose of this study was to observe Side Effects (weight gain, Blood Pressure, Sedation and Extra Pyramidal Side Effects) of Anti-Psychotics (Chlorpromazine, Haloperidol Vs Olanzapine, Risperidone). Method: A prospective observational study has been carried out in Government General Hospital, Guntur for a study period of 6 months i.e., March-August 2014. Number of patient enrolled with antipsychotics were Haloperidol (n=15), Chlorpromazine (n=15), Risperidone (n=35) and Olanzapine (n=25), a total of (n=90) patients. Results: Olanzapine resulted in 4kg and risperidone of 2kg increased weight were seen. Extra pyramidal side effects observed with haloperidol and risperidone were dystonia, tremors and rabbit syndrome. A sedation profile observed with chlorpromazine (80%), olanzapine (36%) and their incidence of sedation was compared, which shows that chlorpromazine caused more sedation than olanzapine in case of schizophrenic patients. Conclusion: Prominent Side effects were observed with haloperidol, and risperidone compared to olanzapine, and chlorpromazine. Weight gain was much observed with olanzapine than risperidone. Sedation was more with chlorpromazine than olanzapine and extra pyramidal side effects were predominantly found with haloperidol, whereas the metabolic side effects predominated the atypical antipsychotics.

Keywords: schizophrenia, anti-psychotics, weight gain, sedation, extra pyramidal side effects.


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