Abstract

TO CARRY OUT PHARMACOLOGICAL EVALUATION OF ANTIDEPRESSANT POTENTIAL OF BOSWELLIA SERRATA IN ALLOXAN INDUCED DIABETIC RAT

Mr. Shankar Datta Gore*, Dr. Hemant V. Kamble, Mr. Sugriv Ghedke, Mr. Dhananjay

Abstract

One of the major health issues facing the world today is diabetes mellitus, whose rising incidence is linked to problems like depression. When depression and diabetes coexist, the management and prognosis of both illnesses are considerably poorer. In this work, a rat model of diabetes-induced depression is used to examine the therapeutic potential of Boswellia serrata extract treatment. Biochemical and behavioral alterations were measured using alloxan to cause diabetes. Oxidative stress, neurotransmitter levels, and neurobehavioral outcomes like as immobility in forced swim and tail suspension tests were the main areas of attention. As a result of notably lowering blood glucose levels, immobility duration, and oxidative stress markers, the Boswellia serrata extract was found to be an efficient means of alleviating depression symptoms in diabetic rats. Based on these findings, Boswellia serrata appears to be a viable herbal treatment option for diabetes-related sadness.

Keywords: Diabetes mellitus, depression, Boswellia serrata, Fluoxetine, alloxan, oxidative stress, diabetes-induced depression.