Abstract

PHYTOCHEMICAL ANALYSIS AND ANTIPYRETIC ACTIVITY OF EXTRACT OF THE AEGLE MARMELOS LEAVES ON DIFFERENT MODELS

Ch. Jyothi*, Hemamalini K., K. Sneha, P. Mallika, P. Keerthy Reddy, B. Roja and Md. Ruksana

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Abstract

The current treatment for fever is NSAIDs. However, NSAIDs cause damage to the liver and kidneys, inhibit COX-1, which affects the digestive system, and increase the risk of blood clots. As a result, efforts are being made to develop powerful antipyretic drugs from medicinal herbal plants. Aegle marmelos (Bael) is a popular medicinal plant in the Ayurveda and Siddha systems of medicine and folk medicines used to treat various disease and disorders including fever. The present study was undertaken to evaluate the antipyretic property of Aegle marmelos (L.) Correa leaves (Family: Rutaceae) on different induced pyrexia models in albino rats. The yeast induced pyrexia method was standardized first by injecting 12.5% yeast suspension (s.c) followed by recording the rectal temperature at regular intervals. It reveals that the ethanolic extract, at dose of 200 mg kg-1 body wt. and 400 mg kg-1 body weight, produced significant (p

Keywords: Aegle marmelos, Brewer‘s yeast, Paracetamol, Pyrexia, TAB vaccine.