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Dr. Dhrubo Jyoti Sen
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Abstract

RESVERATROL-PHOSPHOLIPID COMPLEXES (PHYTOSOMES) WITH IMPROVED PHYSICOCHEMICAL PROPERTIES FAVORABLE FOR DRUG DELIVERY VIA SKIN

Bhupen Kalita and Malay K Das*

Abstract

Phyto-phospholipid complex (phytosomes) is helpful in enhancing oral bioavailability and transdermal permeation of polyphenols. The present work was aimed to deliver Resveratrol (RSV) via the skin in the form of phytosomes to utilize its anti-inflammatory effect. Resveratrolphytosomes (RSV-P) were prepared in various ratios of RSV to phosphatidylcholine (PC). These formulations were found more aqueous soluble than pure RSV (0.0770 ± 1.66 mg/ml). RSV-P also showed n-octanol/water partition coefficient in the range 1.16-1.92 favorable for skin penetration. Drug and phospholipid compatibility was established by the DSC and FT-IR study. SEM images and XRD diffractograms revealed the reduction in crystallinity of RSV in the complexes. Also SEM as well as TEM images showed the round and regular vesicular structure of RSV-P with particle sizes in the range of 1m. Selected formulation when tested for 24 hours long ex vivo skin permeation showed higher skin penetration and retention at dermal sites compared to free RSV. It is hypothesized that the RSVP would give sustained therapeutic effect in acute and chronic inflammation.

Keywords: Resveratrol; phospholipid; phytosome; drug delivery; skin; antiinflammatory.


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