Abstract

SCIENTIFIC EVALUATION OF GAJAPURISAKSARAPAKVA AVALGUJA PRALEPA- A CLASSICAL AYURVEDA FORMULATION

Anoma Geethani Samarawickrama*, Chamila Jayawardana

.

Abstract

Physico-chemical and phytochemical standards are of enormous consequence in assese the quality, purity and authenticity there by, efficacy of the herbal drugs. In the present scenario, the demand for herbal products is increasing exponentially throughout the world, and main pharmaceutical companies are conducting wide-ranging research on plant materials for their latent medicinal significance. Therefore, quality control for the worth and protection of herbal products is essential. Gajapurisaksarapakva Avalguja pralepa is a classical formulation mentioned in Chakradatta under kushta Adikariya. The pralepa of Gajapurisaksarapakva Avalguja consists three ingredients, viz., Elephant Dung, Elephant Urine, and Bakuchi Seed (Psoralea corylifolia). The attempt has been made to study Gajapurisaksarapakva Avalguja pralepa from physico-chemical and phytochemical standardization. The present study was designed to assess the quality of the Gajapurisaksarapakva Avalguja pralepa according to standard protocols. TLC fingerprint developed for Gajapurisaksarapakva Avalguja pralepa.0.1- 0.2 ml of ethanol. Gajapurisaksarapakva Avalguja pralepa was prepared according to the method described in Sushruta Samhita/Prathisaraneeya Kshara Kalpana. According to the results, Gajapurisaksarapakva Avalguja pralepa appeared brownish colour, sharp ordor and semi solid in nature. Physicochemical analysis of Gajapurisaksarapakva Avalguja pralepa showed water soluble ash 0.23 ± 0.02 % w/w, acid insoluble ash 0.12 ± 0.01 % w/w, total ash content 4.46 ± 0.21 % w/w, pH of 7.51±0.32 and loss on drying of 8.± 0.05 %w/w at 105 °C. The present study disclosed that the ethanol extract of Gajapurisaksarapakva Avalguja pralepa and its preliminary phytochemical screening exhibited the presence of various secondary metabolites viz. alkaloids, phenols, steroids, saponin, tannins, flavonoids, and resin. This study would provide preliminary scientific evidence for Gajapurisaksarapakva Avalguja pralepa. Therefore, the Physicochemical and Phyto-chemical parameters of Gajapurisaksarapakva Avalguja pralepa are essential in order to achieve authentic and standard drug for therapeutic purpose and the built-up of new drug.

Keywords: Gajapurisaksarapakva Avalguja pralepa, Kushta adhikariya, Physicochemical and Physico-chemical.