Abstract

INNOVATIVE BILAYER TABLETS FOR GERD: A STUDY OF VONOPRAZAN IR AND DOMPERIDONE SR COMBINATION

Prakash Murugan*, Punitha A. and Murugan Muthukrishnan

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Abstract

This study aims to develop and evaluate a bilayer tablet containing Vonoprazan in the IR and Domperidone in the SR layer. The immediate-release layer of Vonoprazan was created using three superdisintegrants such as starch sodium glycolate, crospovidone XL 10 and crosscaramellose sodium in different concentrations (3, 6 and 9mg) for each formulation. In contrast, the domperiodone sustained release layer was formulated by using three different grades of hydrophilic matrix former HPMC (K4M, K15M, and K 100 M premium CR) with 18 and 27mg concentration for each of the formulation. The prepared bilayer tablet was evaluated for physical appearance, weight variation, thickness, hardness, friability, assay and in-vitro dissolution studies. The results revealed that F9 formulation of vonoprazone layer with crosscaramellose sodium of 9mg has better release (99.17±0.27 at 1hr) whereas domperidone layer shows the drug release of 98.4 at 24hrs while using 27mg of Hypromellose K-100 M Premium CRwhen compared to all other formulations.

Keywords: Bilayer tablet, Vonoprazan Immediate release, Sustained release, Gastroesophageal reflux disease.