Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF ONDANSETRON HCL NATURAL VESICLE OF LIPOSOME FOR CHEMOTHERAPY INDUCED NAUSEA VOMITTING

Giram P. S*, Bare A.R, Puranik P.k and Barkule A.B.

Abstract

aim of present work was evaluation of liposomes by 32 factorial design study of ondansetron Hcl liposome for physicochemical characterization was carried out by using scanning electron microscopy, zeta sizer, particle size analyser and freeze fracture performed. The optimized batch of liposome has zeta potential was (-55.12 mv) and the vesicle size found to be 272.9 nm (PDI = 0.200). In-vivo relese study performed using guinea pig skin through franz’s cells for (24 hr) by RP-HPLC. Liposome suspension shows higher flux than plane liposomes by hyton and chains analysis. Gel prepared by using carbopol (940) shows pesudoplastic flow. Ondansetron Hcl undergoes first-pass metabolism, so its bioavailability may be improved when delivered through transdermal route. Here attempt to increase delivery of ondansetron Hcl by virtue liposomal based vesicular system.

Keywords: vesicle, 32 design, ondansetron HCl, Liposomes, soya lecithin.