Abstract

INNOVATIVE CANCER MANAGMENT STRATEGIES AND DRUG DELIVERY METHODS

*Mane Dhananjay Shivaji, Salunke Sanjana Sunil and Shegade Pooja Rajendra

Abstract

Cancer is one of the leading causes of morbidity and mortality globally, and current treatment options, including chemotherapy, radiation, and surgery, confront substantial limitations such as poor selectivity, systemic toxicity, and drug resistance. Novel drug delivery systems (NDDS) have emerged as a promising way to increase cancer therapy efficacy by increasing medication targeting precision, minimising side effects, and overcoming drug resistance. This study focusses on current advances in various NDDS, such as nanoparticles, liposomes, micelles, dendrimers, and exosomes, which have shown considerable promise in cancer therapies. These systems can improve drug solubility, shield therapeutic compounds from early degradation, and enable controlled and long-term drug release at the tumour site. Furthermore, the addition of stimuli-responsive mechanisms and active targeting techniques has increased the therapeutic index of anticancer drugs. The paper also examines the problems of clinical translation, such as scalability, biocompatibility, and regulatory concerns, emphasising the importance of interdisciplinary approaches to overcome these barriers. Overall, NDDS have great potential to revolutionise cancer treatment, paving the way for more effective and less toxic therapies.

Keywords: novel drug delivery systems, cancer treatment, nanoparticles, liposomes, targeted therapy, drug resistance.