Abstract

SYNTHESIS AND CHARACTERIZATION OF SOME NEW ISOXAZOLES IN SEARCH FOR NEW THERAPEUTIC AGENTS

Ravindra V. Jiyani* and Dr. Viral R. Shah

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Abstract

The Clasien-Schmidt condensation of substituted acetophenones and substituted benzaldehydes were used to synthesize chalcones such as, (E)-3-(2,3-dichlorophenyl)-1-arylprop-2-en-1-one, (E)-3-phenyl-1-(3- (aryl) prop-2-en-1-one and (E)-1-(aryl)-3-(quinolin-6-yl) prop-2-en-1- one. The resulting chalcones were get converted to 3-(2,3- dichlorophenyl)-5-(aryl) isoxazole, 5-(aryl)-3-phenylisoxazole and 5- aryl-3-(quinolin-6-yl) isoxazole derivatives. All the synthesized compounds are characterized by spectroscopic data. Using standard as the reference medication, all of the synthesized compounds were evaluated for them in vitro antibacterial and antifungal activity. BCBR1- 2-CF3& JT-R3-4-OMe found to be a promising compound in their antimicrobial activity as compared to other synthesized molecules.

Keywords: Isoxazole, Chalcones, Antibacterial, Antifungal.