Abstract

FUNDAMENTALS OF PRONIOSOMES: STRUCTURE & COMPOSITION, AND CORE PRINCIPLES

Ashutosh Sengar*, Sourin Saha, Lalit Sharma, Hemlata, Prerana Sanjay Saindane, Sajeeb Dash Sagar

.

Abstract

Proniosomes are an advanced form of drug delivery system that are gaining prominence due to their stability, convenience, and efficiency. These solid colloidal particles, when hydrated, convert into niosomes—microscopic vesicles capable of encapsulating both hydrophilic and hydrophobic drugs. Proniosomes offer a significant advantage over traditional niosomes by addressing key issues such as aggregation, fusion, and drug leakage, thereby enhancing physical stability. Their dry, free-flowing nature facilitates easier transportation, storage, and dosing, making them more suitable for practical pharmaceutical applications. Proniosomes are typically prepared using water-soluble carrier materials, such as maltodextrin, which are coated with non-ionic surfactants. Upon hydration in warm aqueous media, they swiftly transform into niosomes, which prolong drug circulation in the system and target specific tissues more effectively, thus reducing toxicity. This vesicular system also outperforms conventional liposomes, as it avoids the high costs and purity issues associated with phospholipids. Technological advancements in nanotechnology have led to the development of these vesicular drug delivery systems, which have shown potential in improving oral bioavailability, controlled drug release, and targeted drug delivery. The stability and versatility of proniosomes make them ideal for various administration routes, including transdermal, oral, ocular, and intranasal. This article delves into the fundamental aspects of proniosomes, exploring their structure, composition, and the core principles that make them a superior alternative in drug delivery technology.

Keywords: .