Abstract

LEUCAS BIFLORA: REVIEW AND PHARMACOLOGICAL ACTIONS

S. Shervin Jose* and V. Jenila Jose Jancy

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Abstract

Perennial plants like Leucas biflora are found all over India. It belongs to the Lamiaceae family. The leaf of Leucas biflora has various pharmacological action The silver nanoparticles (LbLE-Ag-NPs) from leaf extract was treated with breast cancer cell line MDA-MB-231 and the results showed an efficient dose-dependent anti-cancerous action. The lowest inhibitory concentration (IC50) value was 95 ± 0.21 μg/ml. Fluorescence-based labeling provided additional evidence that the therapy had induced apoptosis. In vitro tests were conducted to determine the scavenging capacity of Leucas biflora's ethanolic leaf extract. The IC50 values for DPPH and ABTS radical scavenging were 15.35 and 13.20 μg/ml, respectively and they have dose-dependent cytotoxicity against HELA cervical cancer cells and A549 lung cancer cells. Leucas biflora ethanolic leaf extract dramatically reduces the viability of both HELA and A549 cells in vitro cytotoxicity assays. Testing Leucas biflora ethanolic extract against A549 lung and HELA cervical cancer cell lines, respectively, reveals viability rates of 23.76% and 29.76%. These extracts had somewhat different IC50 values, 95.80 and 90.40 μg/ml. In the disc-diffusion assay, the plant extract exhibited antibacterial properties against gram-positive and gram-negative bacteria. The methanolic leaf and stem extract of Leucas biflora (Vahl) R.Br. had an anti-inflammatory impact on endotoxin-induced uveitis in Swiss Albino rats.

Keywords: Leucas biflora, Lamiaceae, Pharmacology, Anti-Cancer, Anti-inflammatory.