Abstract

A REVIEW ON NOVEL DRUG DELIVERY TECHNOLOGY CONSISTING OF FLOATING DOSAGE FORM WITH PULSATILE DRUG RELEASE

K. Nagaraju* and T. Sathishkumar

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Abstract

The formulation of pulsatile release drug delivery systems is a reservoir or matrix system, which can include one or more units and is intended to deliver drug levels that are either constant or virtually constant over a prolonged period of time. One such system is pulsatile drug delivery, which holds great promise and benefits patients with chronic conditions like arthritis, asthma, hypertension, etc. by delivering medication at the appropriate time, place, and amount. This increases patient compliance and provides both spatial and temporal delivery. The fundamental argument for the usage of pulsatile release of the medications is where a steady drug release is not desirable. It provides an overview of these systems' release profiles, formulation characteristics, and most recent technological advancements. These systems are useful for medications with chronopharmacological characteristics, such as anti-arrhythmic and anti- asthmatic ones, that need to be taken at night. A single dosage form included a first dose of the medication, one release free interval, a second dose of the medication, subsequent release free intervals, and drug release pulses. One of the main objectives of medication delivery is to be able to administer a therapeutic agent and bioactive chemical to a patient in a pulsatile release profile.

Keywords: Chronotherapy, Floating pulsatile release tablet, burst release, Rupturable, Controlled release drug delivery, Rupturable, Erodible, lag time, swelling index.