Abstract

OVERCOMING THE LIMITS: INVESTIGATING THE FRONTIERS OF EPILEPSY RESEARCH

S. Karthick*, M. Aruna and Dr. R. Manivannan

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Abstract

Even after receiving corrective brain surgery for epilepsy, a sizable portion of individuals still experiences seizures. We are still unsure of the cause of this resistance to therapy. Therefore, we must thoroughly investigate epileptogenesis to develop a treatment for the difficult-totreat form of epilepsy. Most research on drug-resistant epilepsy (DRE) to date has focused on reducing the levels of antiepileptic medications near their targets and disrupting the abnormal activity of receptors involved in synaptic transmission. This theory posits that local neurons utilize complex oscillatory circuits to attract distant neurons, which subsequently draw in even more distant neurons, resulting in hypersynchronous neuronal activity. Patients who experience ischemic and hemorrhagic strokes affecting the thalamus, basal ganglia, and/or their connections have been observed to exhibit involuntary movements, occurring in 1–4% of cases after a stroke. While dystonia is more common in children, hemichorea and hemiballismus are the most frequent movement disorders in adults following a stroke. Other movement problems observed after a stroke include vascular parkinsonism, myoclonus, asterixis, tremor, and stereotypies. Although a larger percentage of patients report that their symptoms have resolved, early detection and management are crucial due to the disabilities that result from these conditions, which include social, financial, and occupational burdens, as well as the need for effective treatment.

Keywords: EEG, Cardiac Investigation, Population, Mortality, Levetiracetam.