Abstract

PROTEIN FACTORS REGULATING THE HUMAN DEFENSE CELLS: INVOLVEMENT OF GLYCOCONJUGATES

Lakhtin V. M.*, Lakhtin M. V. and Aleshkin V. A.

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Abstract

An analysis of the influence of glycoconjugates and carbohydrate moiety on protein factors modulating the activity of protective cells was carried out, including emphasis on the current state of problems in the relationship of protein macrophage-activating factors (MAFs). The prospects of using synthetic polymer glycoconjugates using the patterns of protein/glycoprotein-glycoconjugate interactions established by the authors and based on highly sensitive microanalysis methods developed with the participation of glycoconjugates of monoand assembly molecular targets associated with membranes in the study of prophylactically and therapeutically significant (glyco)(lipo) proteins and (glyco)(lipo)peptides, including those affecting cellular population communications on the examples of MAFs and their peptide derivatives (beta-lactoglobulin, GcMAF, immunoglobulins, others) of colostrum, milk and probiotic cultures, are considered.

Keywords: Cell activation factors, MAF, GcMAF, beta-lactoglobulin, macrophages, glycoconjugates, glycoproteins, recognition, assembly, protection, multiple forms, lectinbiotics, enzymebiotics.