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Abstract

DYNAMIC DISSOLUTION AND STABILITY STUDY OF EFAVIRENZ TABLET TO CHECK THE SUITABILITY OF THE UV METHOD FOR TABLET DISSOLUTION STUDY OF THIS SINGLE COMPONENT FORMULATION.

Ajit.K.Nangare*, Abhishek.K.Shinde, Karan.K.Pawa, Amit N Chavan

Abstract

Efavirenz is one of a new class of anti –viral drugs called nonnucleoside reverse transcriptase inhibitor (NNRTI). It offers the unique therapeutic prospect of treatment & management of disease and so used extensively as a single component formulation. Recently it is under clinical trials in combination with other anti-viral agents. There are no official methods reported for estimation of efavirenz. Literature survey has indicated that there are few spectrophotometric methods for its estimation in human plasma and urine. Objective of this study is to check the suitability of the UV method for tablet dissolution study of this single component formulation and also stability study of efavirenz in 0.1m HCl is studied in this study. Percentage drug release at 60 min is maximum as per the cumulative dissolution calculations.

Keywords: Efavirenz, Anti-Viral, Dissolution study, Zero order spectrum method, Stability study.


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