Abstract

PRELIMINARY PHYTOCHEMICAL SCREENING AND EVALUATION OF ACUTE ORAL TOXICITY STUDY OF SANDHIVAATAARI GUTIKA – A HERBOMINERAL DRUG ON EXPERIMENTAL RATS

K Aruna Gayathri*, K.V. RamSubbarao and K.Ramanjaneyulu

Abstract

Sandhivaataari gutika – a herbomineral drug used in the treatment of osteoarthritis was evaluated in an acute oral toxicity study in a Male Wister rats. Animals were divided into two groups of seven animals each. One group was administered with 2000mg/kg body weight and other group was administered with 5000mg/kg body weight in acute oral toxicity study. The text substance was administered in single dose leval.Signs of toxicity were observed every hour for the first 6 hrs and every day for 14 days. There were no mortalities or clinical signs observed in rats in the acute oral toxicity study. The high no observed adverse effects level (NOAEL) value of 2000mg/ kg and 5000mg/ kg body weight in both groups implies that the drug could be safe. The drug is tested for preliminary phyto-chemical screening It is positive for Cardiac glycosides, Anthroquinone glycosides, Tannins and phenols and negative for Alkaloids, Carbohydrates, proteins and Flavonoids

Keywords: Sandhivaataarigutica, Acute toxicity, Herbomineral formulation.