Abstract

PHARMACOLOGICAL ANTI-HEPATOTOXIC ASSESSMENT OF POLYHERBAL FORMULATIONS LIV-AMRIT SYRUP, LIVAYU LIVER CARE CAPSULES, AND LIVOMAP SYRUP

Kavita Kumari Gaur*, Amrita Singh and Bhanu P. S. Sagar

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Abstract

In present investigation, anti-hepatotoxic activity of Liv-Amrit Syrup (Patanjali), Livayu Liver Care Capsules (Dr Vaidya’s) and Livomap Syrup (Maharishi Ayurveda) against rifampicin and atratyloside was undertaken. Livayu Liver Care Capsules (560 mg/capsule) was found to contain 16 Medicinal Herbs (188 SPMs) as herbal ingredients which produced synergism. Subsequently, Liv-Amrit Syrup (456 mg/15ml) was found to contain 14 medicinal plants (164 SPMs) as herbal ingredients. Further, Livomap Syrup was found to contain 13 Herbal Drugs with 142 SPMs. In anti-hepatotoxic activity, R-CIN in combination with ATR produced severe hepatic necrosis, degeneration, with elevated in LFTs due to necrosis. Oral administration of Liv-Amrit Syrup, Livayu Liver Care Capsules produced significant alleviation of LFTs parameters, reversal effects. Silymarin (standard) induced better alleviation of LFTs. and finally Livayu Liver Care Capsules and Liv-Amrit Syrup polyherbal formulations induced significant anti-hepatotoxic activity (comparatively lesser anti-hepatotoxic effects then standard reference drug i.e. Silymarin). In thiopentone sodium sleep induced analysis it was found that in toxic control animals, R-CIN in combination with ATR induced hepatotoxicity exhaust glutathione stores, reduced onset of sleep and increased duration of sleep and liver-weight ratio was also increased.

Keywords: Rifampicin, Atractyloside, glutathione, Liv- Amrit Syrup, Livomap Syrup, Livayu Liver Care Capsules, Liv-Amrit Syrup, Secondary Plant Metabolites, Silymarin,