Abstract

REVIEW ON FORMULATION AND EVALUATION OF TOPICAL GEL

G. Hariharaputhraayyanar*, C. Arivazhagan, A. Bhuvaneshwaran, M. Dhanush, J. Jayabharath and T. Keerthan

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Abstract

Topical drug administration refers to a localized method of delivering medication throughout the body via various routes, including ophthalmic, rectal vaginal, dermal application. The skin, being one of the most accessible organs, serves as a primary route for topical drug delivery. The topical gel represents a safe and highly effective treatment option for managing skin-related conditions. These gels are designed for localized action, thereby minimizing the side effects commonly associated with traditional dosage forms. A gel consists of a cross-linked polymer network that is swollen in a liquid medium, with its properties being significantly influenced by the intersection between the solid-state polymer and the liquid component. The gel was formulated by using different gelling agent like Carbopol 934, hydroxypropyl methyl cellulose (HPMC), poloxamer, guar gum the gel formulation was evaluated for their drug content, PH determination, in vitro diffusion properties, potential for skin irritation and anti-fungal efficiency. The effective administration of medication for topical application as proven to be significantly advantages in targeting the drug to the intended area of the skin, while also minimizing the side effects commonly associated with traditional treatment.

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