Abstract

EVALUATION OF COMPARATIVE EFFICACY OF INTRALESIONAL APAMARGA KSHARODAK VERSUS INTRALESIONAL CIDOFOVIR IN THE MANAGEMENT OF CHARMAKEELA (WARTS)

Dr. Naveen Singh* and Dr. Devyani Dasar

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Abstract

Background: Charmakeela is an ancient term denoting a nail-like or skin attachment, recognized since antiquity for its cosmetic significance. It's classified as a minor ailment (kshudraroga) by Acharya Sushrutha, with its pathology attributed to an imbalance of vyana vata and kapha affecting the skin, resulting in the formation of a firm, nail-like protrusion termed Charmakeela. Its characteristics vary depending on the dominant dosha: dry and painful for Vata dominance, dark-colored for Pitta dominance, and oily with nodules for Kapha dominance. This condition shares similarities with warts based on classical indications and symptoms. In modern understanding, warts, typically caused by Human Papillomavirus (HPV), are a common dermatological issue. Sushrutha discusses Charmakeela within the framework of Kshar Karma, a therapeutic procedure utilizing caustic alkaline substances. Kshara, renowned for its cleansing and antibacterial properties, aids in the healing process. Ksharodak, a solution containing alkalis, is recognized as a beneficial therapy for Charmakeela (warts). Aim: Evaluation of comparative efficacy of Intralesional Apamarga Ksharodak versus Intralesional Cidofovir in the management of Charmakeela (Warts). Materials: Numerous sources on Ayurveda abound, including ancient texts like the Samhitas, online materials, scholarly articles, and published books. Methodology: After analyzing the drugs, 60 eligible individuals will be selected and split into two groups of 30 each. Group A will receive a single dose of Intralesional Cidofovir, while Group B will receive a single dose of Intralesional Apamarga Ksharodak. Assessments will occur on the second, fourth, and sixth days post-intervention, followed by follow-ups on the eighth and fourteenth days. Results: The findings from assessing both subjective and objective characteristics will yield outcomes. Conclusion: The study's findings will be drawn from statistical analysis conducted on the gathered data.

Keywords: Sushrutha Samhitha; Ksharodak; Human Papilloma Virus; kshanana; Charmakeela; Warts.