Abstract

DESIGNING A FORMULATION TO ENHANCE SOLUBILITY AND DISSOLUTION RATE

Tiwari Sumit*, Vishwakarma Radhika, Tarmale Pooja and Turerao Mallika, Nasikkar Zaynab

.

Abstract

The present study was aimed to enhance the solubility of poorly water soluble drug Ibuprofen using solid dispersion technique and to develop solid dispersion. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory properties. Solid dispersions of Ibuprofen were prepared by using urea, dextrose and HPMC in different weight ratios by fusion, solvent evaporation an kneading method. Drug-carrier physical mixtures were also prepared. Solid dispersions were characterized by saturation solubility, in vitro dissolution, FTIR and DSC analysis. Solid dispersion formulation prepared 1:3 ratio of drug and polymer urea was considered as the optimize formula. The prepared formulations were evaluated for in vitro dissolution studies. Solid dispersion formulation, prepared using 1:3 ratio of ibuprofen and urea showed 88.65% drug release in 90 min in 0.1HCL and considered perfect performance as required. Solid dispersions of ibuprofen using a combination of urea by may result in higher aqueous solubility of the drug.

Keywords: Solid dispersion, Ibuprofen, Urea, Dextrose, HPMC, Sustained Release.