Abstract

UNDERSTANDING NEURODEGENERATIVE DISEASES: A COMPLEX SPECTRUM OF AGE-RELATED DISORDERS

Pooja G. Gund*, Ajit B. Tuwar, Megha T. Salve

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Abstract

Neurodegenerative diseases (NDDs) are a heterogeneous group of agerelated disorders affecting millions worldwide, characterized by progressive neuronal loss in the central and peripheral nervous systems. These diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and others, are marked by the disruption of neural networks and the irreversible loss of terminally differentiated neurons. The increasing prevalence of NDDs, partly attributed to the growing elderly population, underscores the need for a deeper understanding of their underlying mechanisms. Oxidative stress, characterized by excessive reactive oxygen species (ROS) production, has been implicated in NDDs, highlighting the importance of exploring the intricate relationships between aging, neural degeneration, and ROSmediated damage. This project aims to delve into the complexities of NDDs, shedding light on the pathophysiological processes underlying these devastating disorders and paving the way for the development of effective therapeutic strategies.

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