Abstract

FORMULATION AND DEVELOPMENT OF HERBAL GEL CONTAINING CANNABIS SATIVA AND AZADIRACHTA INDICA LEAVES EXTRACT FOR ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITY

Shiva Rana* and Dr. Deovrat Kumar

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Abstract

Bacteria are everywhere and play a crucial part in the maintenance of germs that cause illness and disease. Skin infections are anticipated to occur at a rate of 24.6 per 1000 people yearly. The treatment of any skin infections primarily consists of any necessary surgical debridement; nevertheless, injecting an antibiotic directly into a wound has several potential benefits. Topical antibiotic treatment and wound care are recommended. The administration of a therapy may allow treatment with medicines that are not yet available (or safe) for systemic therapy. Gels are semi-solid systems having qualities intermediate between solids and liquids, in which the movement of the dispersing medium is constrained by an interlacing three-dimensional network of particles or solvated macromolecules of the dispersed phase. This study aimed to explore the potential of Cannabis sativa, Azadirachta indica leaves extract as anti-inflammatory and antibacterial agents. The formulation have been developed by solvent casting method. The experiment was conducted using various techniques to measure the effectiveness of each substance individually and in combination. Results showed that Cannabis sativa and Azadirachta indica leaves extract both had strong anti-inflammatory properties, while glycerol demonstrated significant antibacterial activity. When combined, these substances exhibited enhanced anti-inflammatory and antibacterial effects, indicating potential for their use in pharmaceutical and medical applications. Overall, this study highlights the importance of exploring natural products for their therapeutic potential and provides insight into the potential of these substances as novel anti-inflammatory and antibacterial agents.

Keywords: Anti-inflammatory, Novel gel, Cannabis sativa, Azadirachta indica extract, Anti-bacterial agent.