Abstract

PARADOXICAL AFFINITY OF SELF SERUM CAPPED ANIONIC SILVER NANOPARTICLES TOWARDS HIGH NEGATIVE CHARGED MICROBES AND CANCER CELLS

Dr. Prasanta Kumar Maiti, MD*

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Abstract

Following intravenous use of Colloidal silver nanoparticles (AgNPs) intended for target specific delivery of a bulk toxic atoms, satisfactory outcome essentially demands haemo-compatibility and wide margin of safety to the host. Well buffered, matched serum can be source of best tolerable capping and reducing agents for such therapeutic purposes. Chance of materialistic state alterations in-vivo by secondary “corona protein cap” formation can be eliminated by using homologous serum. This generates primary corona protein capped novel nanoparticles with wide cluster range, smaller, electrically neutral, or weak negative charge. In prokaryotes, initially small size range AgNPs may overcome weak repelling force and disintegrate cell membrane at contact point by mobilizing positive ions into outer diffuse layer of AgNPs, due to increasing intensity of van der Waals force. Subsequently larger AgNPs can enter through wider membrane-gaps created from inside by super-oxide mediated membrane lipid-peroxidation. Selectivity may be further enhanced by adding target specific antibodies. Anti-biofilm and nonspecific synergism properties of personalized AgNPs, can also be advantageously used for therapeutic purposes. Same nanoproducts may be selectively internalized by receptorligand based endocytosis into strong negative surface charge bearing blood parasites, yeasts, and cancer cells, sparing host cells with identical molecular sign on surface.

Keywords: Silver nanoparticles, Charge-sign, Molecular-sign, Corona protein cap, Margin of safety, Personalized nanomedicine.