Abstract

FORMULATION AND EVALUATION OF NATURAL HERBAL ANTIACNE AS GEL DELIVERY SYSTEMS

Mahmoud Mahyoob Alburyhi*, Maged Alwan Noman and Abdalwali Ahmed Saif

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Abstract

The objective of this study was to produce a Carbopol 940 based gel formula containing an Aloe barbadensis, Allium sativum, Camellia sinensis and Ocimum sanctum extract and evaluate their anti-acne potential. The ethanolic extract was derived from the dried leaves of Aloe barbadensis, Allium sativum, Camellia, sinensis and Ocimum sanctum and was subjected to a phytochemical evaluation. Three gel formulations of Carbopol 940 containing Aloe barbadensis, Allium sativum Camellia sinensis and Ocimum sanctum extract in three different concentrations, i.e., 0.5, 1, and 2% w/w were prepared. These gels were evaluated for their physical appearance, antimicrobial activity, skin irritability, pH, spread ability, and wash ability. The prepared formulas were stable, greenish and homogeneous. None of them showed irritation to the skin. The spread ability (g.cm/sec) and pH of all three formulations were 11.76, 11.50, 12.03,6-7 respectively. Gel-III exhibited the highest antimicrobial potential against Propionibacterium acne, It was revealed from the acne healing studies that the elimination time for the acne treated with Gel-III was two weeks. A formulation gel containing 2%w/w extract showed better antimicrobial activity, physicochemical characteristics, and pharmacological parameters than the other formulations. It can be concluded that the acne healing process was faster with the gel formulation containing 2% w/w of the Aloe barbadensis, Allium sativum, Camellia sinensis and Ocimum sanctum extract, proposing that this formulation is a promising candidate for acne healing.

Keywords: Aloe barbadensis, Allium sativum, Camellia sinensis, Ocimum sanctum, Gel, Anti acne.