Abstract

DESIGN AND DEVELOPMENT OF THE LIQUISOLID COMPACT OF GINGEROL LOADED LOZENGES

Padmapreetha J.*, Pradeepa R. and Premnath M. S.

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Abstract

The work was aimed to design and develop liquisolid compact of gingerol loaded lozenges for increasing the solubility of gingerol. The formulation was characterized for drug-excipient interaction using FTIR, DSC, XRD, and drug content analysis. The drug content for the optimized formulation was obtained to be above 97.82 %. The lozenges formulation was optimized based on evaluation parameters such as weight variation, hardness, friability, and drug content. Based on the evaluation studies F4 was identified as best formulation. Formulation F4 exhibited a drug release profile of 90.08 % and followed the Higuchi model. The satisfactory results were obtained from the stability studies. This technique aims to enhance the solubility in water and bioavailability of the pure drug gingerol.

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