Abstract

“PROTECTIVE EFFECTS OF CURCUMIN AGAINST ADRIAMYCIN INDUCED MICRONULEI IN BONE MARROW CELLS OF MICE.”

J.Karuna Kumari and K. Rudrama Devi*

Abstract

Adriamycin (ADR) (doxorubicin) is one of most effective chemotherapeutic agents and is the most commonly used anthracyclin antibiotic effective in treatment of various cancers. Adriamycin induces mutations and chromosomal aberrations in normal and tumor cells. Adriamycin has high affinity for cell nuclei and about 60% of total intracellular adriamycin is found in cell nucleus and binds to DNA polymerase and inhibits synthesis of nucleic acid and protein, results in DNA damage and free radical formation. As Adriamycin is widely used, it is important to reduce its toxicity to normal cells which can be achieved by concurrent administration of antioxidants. Herbs are gaining additional focus because of their less toxicity and high efficacy against a number of ailments. Cucuma longa has been used for broad spectrum of diseases and its isolated compound curcumin found to be anticarcinogenic and a potential antioxidants. In the present investigation studies were carried out to observe the efficacy of curcumin against Adriamycin induced cytogenetic damage in bone marrow cells of mice. The animals treated with 10mg/kg, 15/kg and 20mg/kg of Curcumin showed to be non mutagenic. Curcumin shows protective effects against the adriamycin induced genotoxicity in bone marrow cells of mice. Hence Curcumin supplementation is safer in chemotherapeutic strategy.

Keywords: Curcumin extract, Adriamycin, Micronuclei, Bone marrow cells.