Abstract

INTERACTION KINETICS OF ENROFLOXACIN WITH HYDRATED SODIUM CALCIUM ALUMINOSILICATE – A TOXIN BINDER IN BROILER CHICKEN AUTHORS

Dr. P. Mekala*, Dr. A. Jagadeeswaran, Dr. A. Arivuchelvan, Dr. P. Senthil Kumar,
Dr. K. Nanjappan and Dr. T. R. Gopala Krishna Murthy

Abstract

The study was conducted to explore the influence of hydrated sodium calcium aluminosilicate (HSCAS), a toxin binder commonly used in poultry feed, on the pharmacokinetic behavior of enrofloxacin in broiler chicken. Control group received normal feed free of toxin binder whereas HSCAS group was supplemented with HSCAS @ 0.5% in feed. Enrofloxacin was administered as single pulse dose (@10mg.kg-1) through drinking water to both the groups. Blood samples were collected at predetermined time intervals after drug administration and plasma was separated and analyzed for enrofloxacin concentrations using HPLC. Highly significant (p

Keywords: Pharmacokinetics, Enrofloxacin, HSCAS, Toxin binder, Pulse dosing, HPLC.