Abstract

FUROSEMIDE-EXCIPIENT COMPATIBILITY STUDIES FOR ADVANCED DRUG DELIVERY SYSTEMS DEVELOPMENT

Mahmoud Mahyoob Alburyhi*, Yahya Abduh Salim Mohamed, Abdalwali Ahmed Saif and Maged Alwan Noman

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Abstract

Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Furosemide Orodispersible Tablets to improve the bioavailability of Furosemide. In API development process, a detailed characterization of the API and other formulation components is usually carried out during the preformulation stage. The drug-excipient compatibility studies were conducted to characterize the drug Furosemide present in Orodispersible Tablets Delivery System ODTs. Preformulation, formulation and evaluation of Furosemide to avoid problems associated with conventional delivery system and one of the most recent antihypertensive agents. In the present study that the compatibility was assessed by, FTIR spectroscopy, and melting point apparatus, precompression parameters and powder flow properties. Results showed that physical mixtures of Furosemide and various excipients such as MCC as diluent, and sodium starch glycolate, crospovidone as superdisintegrants and sodium lauryl sulfate as wetting agent were evaluated for preformulation studies parameters. It was concluded that the drug Furosemide was found to be compatible with various excipients which were selected for the formulation development of the Furosemide ODTs. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the ADDS (Advanced Drug Delivery Systems) product development process.

Keywords: Furosemide, Compatibility, Excipients, Development, Preformulation, Formulation.