Abstract

INTERRELATIONSHIP OF VITAMIN B12 AND CORTISOL LEVEL

Dr. Rubeeya Lodhi* and Shaik Abdul Nadim

Abstract

Stress, both physical and psychological, is attracting increasing attention among neuro researchers. In the last 20 decades, there has been a surge of interest in the research of stress induced manifestations and this approach has resulted in the development of more appropriate animal models for stress associated pathologies and its therapeutic management. These stress models are an easy and convenient method for inducing both psychological and physical stress. To understand the behavioral changes underlying major depression, molecular and cellular studies are required. Dysregulation of the stress system may lead to disturbances in growth and development, and may this may further lead to the development of various other disorders. This article reviews the interrelation of Vitamin B12, androgens and cortisol in chronic stress model and their neurobiology, including the different neurotransmitters and heart function affected. There are various complications associated with stress and their management through various pharmacological and Non‑Pharmacological techniques. The use of Vitamin B12 in the treatment of stress related problems is in practice in both Indian and Western societies, Examination of the hyper-responsiveness of the Hypothalamic-Pituitary-Adrenal axis, consequent elevated serum cortisol, Androgens plus the effects of this upon brain structure and function, provides a model for understanding how chronic stress may be a causal vector in the development of major organ dysfunction like CVS dysfunction.

Keywords: Chronic Stress, Vitamin B12, Cortisol.