Abstract

EFFECT OF BUPIVACAINE AND POSACONAZOLE ON ANIMAL MODELS FOR DEPRESSION IN ALBINO RATS

Rajesh M* and Divya R

Abstract

OBJECTIVE: Depression is a disturbance in mood, thought, and body characterized by varying degrees of sadness, disappointment, loneliness, hopelessness, self-doubt, and guilt. Management of depression with Tricyclic Antidepressants, Selective serotonin reuptake Inhibitors and Selective Noradrenaline reuptake inhibitors are troublesome due their side effects, Latency of onset, overdose toxicity and Non-compliance. Anti-depressants like amitriptyline and anticonvulsants like carbamazepine, gabapentin, pregabalin, lamotrigine have been used, but with uncertain efficacy. Hence this study was designed evaluate the antidepressant effect of Bupivacaine and Posaconazole on Forced Swim test and Locomotor activity by Actophotometer in Wister Albino Rats. MATERIALS & METHODS: For this study 30 healthy male albino rats were selected and divided into 6 equal groups. Digital Forced Swim test was conducted to rats of groups 1 to 5, 30 mins after oral administration of following drugs, distilled water, Amitriptyline(2mg/kg), Bupivacaine(5mg/kg) Amitriptyline+Bupivacaine (2mg/kg+5mg/kg) and Posaconazole (40mg/kg) respectively. After two weeks of washout period the same animals were used for testing Locomotor activity using Actophotometer. The results were analysed statistically. RESULTS: Amitriptyline plus Bupivacaine combination treated group showed significant (P < 0.05) antidepressant activity compared to amitriptyline alone treated rats. There was no significant change in the locomotor activity in the amitriptyline, posaconazole, and bupivacaine treated animals. CONCLUSION: Amitriptyline plus Bupivacaine combination has significant antidepressant activity compared to placebo. Posaconazole failed to show significant antidepressant activity.

Keywords: Posaconazole, Bupivacaine, Digital forced swim apparatus, Actophotometer.