Abstract

WOUND HEALING ACTIVITY OF STEM BARK OF TABERNAEMONTANA HEYNEANA (WALL.)

*Dr. Keerthidas, Dr. Shrikanth P. and Dr. Thejaswi I. Naik

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Abstract

Introduction: Folk drugs represent a wealth of traditional knowledge passed down through generations. Many folk remedies have been used for wound healing over centuries. The study and documentation of these remedies are essential for preserving traditional knowledge, validating and potentially discovering new therapeutics, and enhancing treatment options. With the rise of antibiotic resistance and the need for more effective wound care solutions, traditional remedies can offer alternative strategies. Tabernaemontana heyneana (Wall.), belonging to Apocynaceae is one such potential herb mainly used by the folklore practitioners of South Canara and Udupi region of Karnataka effectively in the management of wound. The present study was undertaken to evaluate the wound healing activity of the stem bark of Tabernaemontana heyneana (Wall.) in Wistar albino rats. Methods: The wound healing activity of bark was studied in Excision wound model in rats. The excision wound was made on the dorsal aspect of the rats, measuring an area of 1 cm. The Wistar albino rats were randomly assigned to three distinct groups and administered group-specific medications for a duration of 24 consecutive days. Wound contraction, eschar fall and complete cure day were observed, histopathological and hydroxy proline parameters were carried out on 25th day to assess wound healing activity. Results: In experimental study, percentage of wound contraction and period of epithelialization showed statistically significant when compared to standard and control. The histopathological study revealed the test group with good re-epithelialization. Conclusion: The experimental study results suggests that Tabernaemontana heyneana (Wall.) bark is effective in wound healing compared to Control and Standard group.

Keywords: Tabernaemontana heyneana (Wall.), Excision wound, Wound healing.