Abstract

COMPARISON OF NEUROTOXICITY AND HEMATOTOXICITY ASSOCIATED WITH VINCRISTINE AND VINBLASTINE IN CANCER TREATMENT

Chaitali S. Bhagat*, Hrutwik M. Deshmukh, Deep R. Tope, Narendra D. Umale and Dr. H. S. Sawarkar

Abstract

Vincristine and vinblastine Catharanthines, both derived from the plant Catharanthus, Catharanthus roseus (Cinca roseus), are widely used chemotherapy drugs in the treatment of various malignancies, including leukemia, lymphoma, and cancer. Although the treatments are effective in suppressing cancer cells, these drugs are associated with several side effects that may limit their clinical use. Vincristine is known for its neurotoxicity, mostly causing peripheral neuropathy, motor dysfunction, and autonomic nervous system disorders. Other side effects of both drugs include gastrointestinal upset, hair loss, and, rarely, allergic reactions. This review provides a comprehensive overview of the mechanisms behind the side effects of vincristine and vinblastine, their symptoms, and potential strategies to manage these side effects to improve therapeutic benefits while reducing toxicity.

Keywords: Vincristine