Abstract

SYNTHESIS AND CHARACTERIZATION OF NOVEL OXAZOLE DERIVATIVES OF MORPHOLINO DISUBSTITUTED NARYLMALEIMIDES

Sunita A. Chaudhari (Patil)*, Vasant M. Patil, Ananda S. Kudale, Vishwanath R. Patil and Sambhaji V. Patil

Abstract

The compound 1 was reacted with bromine in DMF to obtained dibromosuccinimides 2. The compound 2 react with morpholine followed by dehydrohalogenation to obtained monobromo compound 3 through common enaminone intermediate. Vilsmeier Haack formylation of compound 3 afforded compound 4 with good yield. Thus, condensation of 1-(4-chlorophenyl)-2, 5-dihydro-2, 5-dioxo-4- (dialkyl-1-yl)-1Hpyrrole-3-carbaldehyde 4 with semicarbazide in ethanol in presence of acetic acid furnished compound 5 with 84% yield. The compound 5 react with substituted phenacyl bromide 6 a-g to obtained oxazole derivative of disubstituted N-arylmaleimides 7 a-g. All the synthesized compounds were well characterized by IR, NMR and elemental analysis given in experimental section.

Keywords: Maleimides, Morpholine, Semicarbazone, Phenacyl bromide and Oxazole.