Abstract

FORMULATION AND EVALUATION OF POLYHERBAL EXTRACT FOR SKIN HYPERPIGMENTATION AS GEL ADVANCED DELIVERY SYSTEMS

Maged Alwan Noman, Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif and Tawfeek A. A. Yahya

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Abstract

Hyperpigmentation is a skin disorder that causes the skin to darken in small patches of certain area or it may cover a large area of the body. Because chemical skin lightening agents may cause adverse effects. The present study focuses on formulation of whitening poly-herbal gel comprising extracts of four medicinal plants include (Licorice, Curcuma longa, Pomegranate peels, and Citrus reticulate Blanco peels), which having significant skin whitening potential for the management of hyperpigmentation problem. These plants have been reported as a good anti-tyrosinase, anti-microbial, antioxidant, antiinflammatory and prevents skin aging. The extraction of Licorice, Curcuma longa, Pomegranate peels, and Citrus reticulata blanco peels were done, and different gel formulation containing 2%, 5% and 10% extract were prepared. Gel was evaluated for physical appearance, consistency, wash ability, homogeneity, pH, spreadability, viscosity, centrifugation test and skin irritation test. Such poly-herbal gel showed good clarity, with yellowish color, translucent appearance, smooth, no grittiness, good consistency, easily remove, good homogeneities, pH, spreadability, viscosity, no phase separation and no skin irritation when applied on the skin for a period of 24 hours. Formulation containing 10% extract appears to be the best formulation followed by 5% then 2%, in case of overall evaluation, such as spread-ability, viscosity, and non-irritancy. These results indicate that the prepared poly-herbal gel formulation has significant potential for skin lightening and treating hyperpigmentation effectively and safely.

Keywords: Hyperpigmentation, Poly-herbal, Melanogenesis, Natural Skin Lightening.