Abstract

REVIEW ON NANOTECHNOLOGY BASED ON OCULAR DRUG DELIVERY SYSTEM

*Petare Trupti S., Gore Aaditee A. and Dr. Megha Salve

Abstract

Ocular drug delivery faces significant challenges due to the eye's complex anatomy and physiological barriers. Conventional eyedrops have limited bioavailability, leading to reduced efficacy and increased systemic side effects. Recent innovations aim to overcome these hurdles. This review discusses. 1. Novel drug delivery systems: nanoparticles, liposomes, microneedles, and implants. 2. Sustained release technologies: contact lenses, ocular inserts, and biodegradable polymers. 3. Targeted delivery approaches: prodrugs, gene therapy, and stem cell-based therapies. 4. Anterior and posterior segment targeting strategies. 5. Challenges, regulatory considerations, and future directions. Recent studies demonstrate improved therapeutic outcomes for glaucoma, age-related macular degeneration, and diabetic retinopathy. Translating these innovations into clinical practice requires addressing scalability, biocompatibility, and cost-effectiveness.

Keywords: ocular drug delivery, nanoparticles, sustained release, targeted therapy.