Abstract

FORMULATION AND EVALUATION OF GASTRO-RETENTIVE ESOMEPRAZOLE MAGNESIUM TRIHYDRATE LOADED FLOATING FILMS

Shamanthakamani S. L.*, Yogananda R., Maruthi N. and T. S. Nagaraja

Abstract

The present study was aimed to develop film which could float on gastric fluid in stomach by releasing the Esomeprazole magnesium trihydrate. It may act as site specific drug delivery system for treatment of Peptic ulcers and GERD. Floating films were prepared by Solvent Casting method varying the Different Conc. of Film former (HPMC K 15 M), Effervescent agent (Sodium bicarbonate) and plasticizer (PEG 400). The Prepared films were Characterized and evaluated for various parameters like FTIR and Film thickness, weight variation, Folding endurance, tensile strength, drug content, in-vitro dissolution studies, Buoyancy, floating time and lag time. From obtained results It can be concluded that Formulation EF6 demonstrated a lag time of roughly 57 seconds, a floating time of 12hrs in 0.1N HCL and also Shown retardance in In-vitro drug release studies of about 88% in 12hrs. So this formulation provides Gastroretentive property for the films in 0.1N HCL.

Keywords: Floating films, Tensile strength, Lag time.