Abstract

FORMULATION AND INVITRO EVALUATION OF GLICLAZIDE MICROBEADS

Krishnaveni Manubolu*, Byna Sujatha, Munna Sreenivasulu, S. Rupesh Kumar, S. Naveen Kumar and K. Bhaskar Rao

Abstract

An attempt was made to formulate and evaluate alginate floating microspheres of gliclazide as a model drug by ion cross-linking technique or ion gelation method using cacl2 as cross-linking agent. The microspheres were formulated using sodium alginate (as release retardant agent) with a view to deliver drug at controlled/sustained manner in GIT and consequently into systemic circulation. The prepared microspheres were evaluated for particle size, angle of repose, % yield,% drug entrapment efficiency, degree of swelling and invitro drug release studies. The release rates were studied using dissolution apparatus. the percentage yield was decreased from F1-F4. This was found to be in the following order 89.755,87.56%,86.91% and 85.62%respectively. The drug entrapment efficiency of the microbeads prepared from sodium alginate alone were found to be in the range of 66.38- 79.62% The average particle size of different formulations were 850,1050,1225,1155μ respectively. The percentage buoyancy of microbeads F1-F4 was increased from 55-86.3% . For F1 formulation the % drug release was 80% at the end of the 4th hour. For F2,F3,F4 formulation at the end of the 4th hour 77.2%,82.8%,84.8% was observed. Large particle size at greater polymer concencentration enhanced the polymer matrix density. The diffusional path length of the microbead increased which ultimately resulted in sustained drug release.

Keywords: gliclazide, alginate beads, ion- crosslinking method, sodium alginate, diabetes mellitus, floating microspheres.