Abstract

A REVIEW ARTICLE ON: MICRONEEDLE PATCHES FOR TRANSDERMAL DRUG DELIVERY SYSTEM

Mr. Abhay Trimbak Athare*, Dr. Megha T. Salve, Mrs. Kalpana S. Kale

Abstract

Transdermal patches have been used for a significant amount of time for drug delivery through the skin. The further development of transdermal technology demonstrated the significant effectiveness of transdermal patches designed for the passive diffusion of medication. The development of transdermal delivery systems continued with the introduction of iontophoresis and sonophoresis. The microneedle array is now gaining interest from researchers due to its great usefulness in transdermal delivery of very large molecules that are ionic and hydrophilic in nature. In this technical note, we discuss the present situation, uses, and latest developments in delivering important molecules through the skin using microneedle arrays. The use of microneedles has been extensively studied, with a focus on developing them for administering biotherapeutics, biomacromolecules, insulin, growth hormones, immunobiologics, proteins, siRNA, and peptides. The potential of microneedles to revolutionize the worldwide transdermal market is emphasized by the successful implementation of microneedle technologies in clinical trials leading to global market entry. The introduction of commercial microneedle products into the market is eagerly awaited due to their potential to have a significant impact on clinical medicine in the coming years.

Keywords: Transdermal Drug Delivery, Skin Permeation, Membrane moderated systems, Adhesive diffusion controlled system, Microreservoir system.