Abstract

PREPARATION AND CHARACTERIZATION OF GLUTARALDEHYDE CROSS-LINKED CHITOSAN- XANTHAN GUM HYDROGEL MATRIX OF CELECOXIB

Sreejan Manna*, Uma Maheswari, Lakshmi Kanta Kanthal, Manasa Racharla, Uppadi Swathi Lakshmi and Nama Sreekanth

Abstract

In present study celecoxib, a selective COX-2 inhibitor was incorporated into glutaraldehyde cross-linked chitosan- xanthan gum hydrogel matrix system. Inter penetrating network of chitosan and xanthan gum was prepared for sustained release of celecoxib by using various concentrations of polymers and cross-linking agent. The drug and formulation were separately studied for FT-IR along with other preformulation studies. Entrapment efficiency for all the formulations were found to be 81.67 ± 1.68 % to 95.45 ± 0.54% (n=3). Swelling study was done and water uptake by hydrogel matrix at pH 1.2 and at pH 7.4 were studied and significant swelling of hydrogel matrix were observed. In vitro drug release study for celecoxib matrix tablets was carried out in three different buffer solutions, (pH 1.2 HCl buffer, pH 6.8 and pH 7.4 phosphate buffers) which showed a typical sustained release pattern throughout the GIT. The effect of xanthan gum on drug release from hydrogel matrix was investigated. The drug release was modified by changing the concentrations of glutaraldehyde and xanthan gum and chitosan. Among all the formulation, F7 was considered as best formulation based on the entrapment efficiency and drug release pattern from polymeric matrix. Kinetics study was done for all the formulations and best fit model for drug release was determined depending on R2 values. Release kinetics of F7 was found to follow zero order kinetics which fits the criteria of drug release from hydrogel matrix system.

Keywords: Glutaraldehyde, chitosan, xanthan gum, cross-linking, hydrogel.