Abstract

A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM – TRANSDERMAL PATCH

Shubhangi Bapusaheb Mhaske*, Priya Arun Walke, Dhananjay Chandrakanat Abhang, Asst. Prof. Jayshri Kasar

Abstract

Transdermal drug delivery system is an essential part of novel drug distribution system. The topically administered medications in the form of patches which when applied to the skin deliver the drug. For operative TDDS the drug are easily able to penetrate the skin and easily reach the target site. TDDS avoids the first pass metabolism, less frequency of administration, reduction gastrointestinal side effects. Adverse effects are minimized due to steady and optimum blood concentration. It has greater bioavailability and efficacy of drug. A transdermal patch is amedicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. Polymer should be chemically non-reactive, should not decompose on storage, should be non-toxic, cost should not be high. E.g. cellulose derivatives, zein, gelatin etc. Backing films play a vital role in the transdermal patch and the role of the film is to protect the active layer. Transdermal patches can be evaluated by interaction studies thickness, weight uniformity, drug content, in vitro study, moisture content, swelling index basic component of TDDS.

Keywords: Human skin, Trandermal routes and permeation, Physicochemical and biological factors, Advance development.