Abstract

POLYCYSTIC OVARIAN SYNDROME

Shelke Vaishnavi Santosh*, Aaditi Gore and Megha Salve

Abstract

Polycystic Ovarian Syndrome (PCOS) is a multifaceted endocrine condition impacting women of reproductive age, marked by symptoms including hyperandrogenism, irregular menstrual cycles, and the presence of polycystic ovaries. Although it is common and significantly affects women's health, the pathogenesis of PCOS is still not fully understood. This review offers an extensive critical evaluation of the current literature regarding PCOS pathogenesis, identifying areas lacking knowledge and emphasizing its multifactorial character. A thorough literature review found pertinent articles published up to the knowledge cutoff in 2023, emphasizing molecular, genetic, hormonal, and environmental elements that play a role in the development of PCOS. Electronic databases such as PubMed, MEDLINE, and Embase were thoroughly searched utilizing specific terms. Qualified studies explored molecular, genetic, hormonal, and environmental elements linked to the development of PCOS. The critical evaluation uncovered various studies that enhance our comprehension of PCOS. Molecular and genetic research has emphasized changes in signaling pathways, hormonal imbalances, and the impact of insulin resistance. Environmental factors, such as lifestyle choices and exposure to endocrine-disrupting substances, were involved. Variability in research designs and methods emphasized the necessity for standardized approaches to improve comparability. This review consolidates existing evidence on the critical assessment and development of PCOS, highlighting its complex nature. Standardizing study designs and methods will enable future comparisons, fostering the creation of targeted therapeutic approaches and personalized management plans for women impacted by PCOS.

Keywords: Polycystic ovary syndrome; Knowledge; Attitude; Complications.