Abstract

THE ROLE OF THE LEADER STRAINS OF SOME SPECIES IN THE ORDERING, INITIATION AND SWITCHING OF SUBPOPULATIONS OF MICROORGANISMS OF OTHER SPECIES COEXISTING IN THE BIOTOPE: PROGNOSTIC CALCULATION OF THE SERIES OF STRAINS OF MICROORGANISMS RANKED BY THE ABILIT

Lakhtin V. M.*, Lakhtin M. V., Bairakova A. L. and Aleshkin V. A.

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Abstract

The concept of the role of the strain leaders of some species (on example of lactobacilli) in the order, initiation, and switching of microbial subpopulations of another species (on example of Candida) coexisting in biotopes has been developed. A view on the role of biofilm formation and its potential application in predicting the behavior, co-functioning, and antagonism of microbes in mucosal biotopes is expanded (using urogenital biotope as an example), as well as assessment of the protective and combat status of microbiocenoses is presented (using Lactobacillus species versus Candida species). For the first time, results of prognostic calculations and analysis of a series of strain microorganisms ranked by their ability to form biofilms in human biotic mixtures are presented along with the proposed concept. The concept and methodological approaches are applicable to any type of organism biotope and any taxonomic groups of microorganisms in human biotopes (populations and subpopulations of genera, species, subspecies and strains), and are key when considering aspects of microbial ecology. Further prospects for application of results in medical microecology are discussed.

Keywords: microecology, biotope, microbiocenose, Lactobacillus, Candida, mixed cultures Lactobacillus—Candida, biofilm forming, ranging formulas, subpopulations, leader strains, antagonism, synergism, probiotic-like lactobacilli, human, patients.