Abstract

BIOADHESION DRUG DELIVERY SYSTEM

Pranita P. Zodape*, Sanskruti B. Gudadhe, Prof. Vishnudas K. Lokhnade, Dr. Rahul.S

Abstract

Since the early 1980 the concept of bioadhesion has gained considerable intrest in pharmaceutical technology. This article focuses on defining the principles of bioadhesive drug delivery system based on hydrogels to biological surfaces that are covered by mucus. It is ideal for the buccal distribution of drugs that have a short biological half-life, a low molecular weight, poor water solubility, an unstable pH, a low dose, and a high first-pass metabolism. There are many routes of mucoadhesive drug delivery system, oral route is the most ancient as well as preferred by patient being convenient to take. The buccal mucosa is very suitable for a bioadhesion system because of a smooth and relatively immobile surface and accessibility. Attention is given to latest breackthroughs such as new polymers, and also adherence to therapy in patients. The bioadhesive polymers can exert control over the rate and extend of drug release and are selected in the formulation of mucoadhesive drug delivery systems.

Keywords: Global adhesion, histoarchitectural features, translucent, cyclodextrin, keshary chie cell, buccostem.