Abstract

SCREENING OF ANTIMICROBIAL POTENTIAL OF OLEANOLIC ACID ISOLATED FROM VISCUM ARTICULATUM BURM.

S.D. Patil*, S. A. Agrawal, Dr. K.R. Biyani and A. M. Agrawal

Abstract

Pentacyclic triterpenoids show promising antibacterial activities. In its free acid form, oleanolic acid (OA) also constitutes an imperative part of cuticular barrier for insect and microbial herbivory in many plants. Its diverse pharmacological properties and low toxicity together with potential as a molecular scaffold for new drug discovery generate remarkable interest in pharmaceutical researchers. With regard to structure-activity relationship of triterpene acids and derivatives, it is suggested that both hydroxy and carboxy groups present in the triterpenes are important for their antibacterial activity against different pathogens. In present investigation isolated oleanolic acid from Viscum articulatum Burm. f. (Viscaceae) which is a parasitic plant and investigated for its antimicrobial activity against selected microbes.

Keywords: Oleanolic acid, antimicrobial activity, MIC, MBC etc.