Abstract

EVALAUTION OF SYNERGISTICALLY GASTROPROTECTIVE EFFECTS OF ETHANOLIC LEAVES EXTRACTS OF ACHYRANTHES ASPERA & EUPHORBIA HIRTA

Jitendra Kumar*, Avinash Joriya and Anand Singh

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Abstract

Objects: In the present study the Synergistically Gastroprotective activity of ethanolic leaves extract of Achyranthes aspera & Euphorbia hirta was investigated in the chemical induced ulcer. The efficacy of the both plants based upon leaves extract was compared with standard reference anti-ulcer drug Ranitidine. Methods: The extracts collected from the both plants of Achyranthes aspera & Euphorbia hirta. Firstly, Both plants leaves of A. Aspera & E.hirta was collecting and reduced to small size after drying in shade for one month or till dry and crushed to form coarse powder. The powdered drug (250 gm) was subjected to continuous hot extraction with the help of soxhlet apparatus using ethanol solvent. The plant material was dry in hot air oven at 500C for an hour. After the effective extraction, the solvents were distilled off, the both extracts were then concentrated on water bath to become dried. The obtained extract was weighing and stored in an air tight container. Result: The modal of absolute 99% ethanol induced ulcer, oral administration of ethanolic leaves extracts and standard drug (20mg /kg/bw) dose showed that reduction in ulcer index, collection of gastric juice, free acidity, total acidity, and also shows the pH of gastric juice and all parameters compared with the control group. It was showing protection index of 52.58%(A. aspera) 59.13% (E.hirta) and 64.10% (A. aspera + E hirta) at the doses of 300, 300, & (100 +300 mg/kg-bw). Omeprazole as reference standard drug and showing protection index of 68.95% at the dose of 20mg/kg-bw. The results are shown in tables and figure for illustration (Tables 1-2 and fig. 1-3).

Keywords: Achyranthes aspera, Euphorbia hirta, Ranitidine, Ethyl alcohol.