Abstract

RECENT ADVANCEMENTS IN LYOPHILIZATION TECHNOLOGY IN PHARMACEUTICAL FORMULATIONS: A REVIEW

Janvi, Khushi, Dr. Asha Gandhi, Mukesh Sharma and Manish Kumar*

Abstract

Lyophilization, or freeze-drying, has been widely used in the pharmaceutical industry for over six decades as a means of preserving sensitive drug formulations, including proteins, vaccines, and biologics. Its importance has only grown in recent years due to the increasing complexity of pharmaceutical products and the need for stability over long storage periods. This review discusses recent advancements in lyophilization technology, focusing on innovations aimed at enhancing process efficiency, improving product stability, and increasing scalability. The review also addresses the challenges faced by the industry and presents potential future directions in lyophilization technology.

Keywords: Lyophilization, Freeze-drying, Pharmaceutical formulations, Drug stability, Biotechnology, Protein formulations, Process optimization, Advanced technology.