WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

INVITRO ANTI INFLAMMATORY AND ANTICANCER POTENTIAL FROM THE ACETONE EXTRACT OF FRUIT OF PHYLLANTHUS ACIDUS. L

N. Padma Priya* and T.V. Poonguzhali

Abstract

P. acidus, locally named as Arbaroi in Bangladesh and gooseberry or star gooseberry in India, is an edible small yellow berries fruit in the Phyllanthaceae family. To evaluate invitro anti inflammatory and anticancer potential from the acetone extract of fruit of Phyllanthus acidus. L. anti inflammatory activity was evaluated using membrane stabilizing activity method. The cytotoxic effect was determined against the cancer cell lines (A549) using MTT assay. The extracts inhibited significant anti inflammatory and anticancer activities at dose dependent manner. Acetone extract showed superior activity which was comparable with standard drugs. At a concentration range of 2- 10μg/mL it protects the human erythrocyte membrane against lysis induced by hypertonic solution. At a concentration of 10 μg/mL the P. acidus fruit extract produced 74.1% inhibition of RBC haemolysis as compared with 80.01% produced by diclofenac sodium. Anticancer activity was found to be concentration dependent. At 1000 μg/mL concentration of P.acidus cell death was observed with least value of 14.2% respectively. The IC50 value of fruit extract of P. acidus was found to be 61.5 μg/mL respectively.

Keywords: Phyllanthus acidus, Anti inflammatory, anticancer.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More