Abstract

INVITRO ANTI INFLAMMATORY AND ANTICANCER POTENTIAL FROM THE ACETONE EXTRACT OF FRUIT OF PHYLLANTHUS ACIDUS. L

N. Padma Priya* and T.V. Poonguzhali

Abstract

P. acidus, locally named as Arbaroi in Bangladesh and gooseberry or star gooseberry in India, is an edible small yellow berries fruit in the Phyllanthaceae family. To evaluate invitro anti inflammatory and anticancer potential from the acetone extract of fruit of Phyllanthus acidus. L. anti inflammatory activity was evaluated using membrane stabilizing activity method. The cytotoxic effect was determined against the cancer cell lines (A549) using MTT assay. The extracts inhibited significant anti inflammatory and anticancer activities at dose dependent manner. Acetone extract showed superior activity which was comparable with standard drugs. At a concentration range of 2- 10μg/mL it protects the human erythrocyte membrane against lysis induced by hypertonic solution. At a concentration of 10 μg/mL the P. acidus fruit extract produced 74.1% inhibition of RBC haemolysis as compared with 80.01% produced by diclofenac sodium. Anticancer activity was found to be concentration dependent. At 1000 μg/mL concentration of P.acidus cell death was observed with least value of 14.2% respectively. The IC50 value of fruit extract of P. acidus was found to be 61.5 μg/mL respectively.

Keywords: Phyllanthus acidus, Anti inflammatory, anticancer.