Abstract

A REVIEW ARTICLE ON GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM

Tannvi Malpotra*, Aanchal Chandel, Dr. Neeraj Bhandari, Ankush Uppal, Ankush Sharma and Shivani Pathania

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Abstract

Gastrorentative drug delivery system is an approach to prolong gastric residence time, thereby targeting site specific drug release in the upper gastrointestinal track (GIT) for local or systemic effects. Gastroretentive dose forms can remain in the gastric region for long period and hence significance prolong the gastric retention tine of drug. GRDDS provide efficient means of enhancing the bioavailability and controlled drug delivery. Innovative pharmaceutical formulations known as gastroretentive drug delivery systems (GRDDS) are intended to increase the bioavailability and therapeutic effectiveness of medications that have poor absorption or solubility in the lower gastrointestinal tract. These systems are designed to keep medications in the stomach or upper gastrointestinal tract for longer, enabling regulated absorption and sustained release over time. GRDDS can be especially helpful for medications that are unstable in the intestines or that need a certain window of time to be absorbed. To accomplish gastric retention, a number of technologies have been developed, including floating, bio adhesive, swellable, and magnetically controlled systems. These methods optimize the drug's release profile, lengthen its residence time, and increase patient adherence. The concepts, design approaches, benefits, difficulties, and potential applications of gastroretentive technology are highlighted in this abstract.

Keywords: Gastro-retentive; Gastric residence time; Stomach; Drug.