Abstract

A REVIEW ON NASO PULMONARY DRUG DELIVERY SYSTEM

Sasikanth Kothamasu*, Maraka Hyma and B. Thangabalan

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Abstract

Nasal drug delivery has received a great deal of attention as a Convenient, reliable and promising method for the systemic Administration of drugs. This is due to high vascularity, large surface Area, the avoidance of hepatic first pass metabolism, gut wall Metabolism and/or destruction in gastrointestinal tract. Since nasal Mucosa offer several benefits for target delivery, a wide variety of Therapeutic compounds may be administered intra nasally for topical, Systemic and central nervous system action. Pulmonary drug delivery has attracted tremendous scientific and biomedical interest in recent Years and has progress considerably within the context of local Treatment for lung diseases, by virtue of enhanced local targeting and Reduced systemic side effects with the administration of minute drug dosages. The present Review is an attempt to provide some information concerning naso-pulmonary drug delivery System such as advantages, disadvantages, mechanism of drug absorption, anatomy of nasal Cavity and respiratory tract, factors affecting nasal drug absorption, dosage form, novel drug formulation and recent advancement of nasal delivery system.

Keywords: Naso-Pulmonary drug delivery, Mucociliary clearance, First pass metabolism, Proteins, Peptides.